{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303008/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Elaphurus davidianus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303008"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Sex- and Age-Dependent Transcriptomic Profiling of Père David's Deer Blood Reveals Molecular Mechanisms Under Captive Conditions","description":"This study presents a comprehensive multi-omics analysis revealing sex-specific and age-dependent physiological activities in the endangered Père David's Deer, a species extinct in the wild and maintained under captive conditions. Blood transcriptomes from 33 individuals (19 males and 14 females) across four developmental stages—Fawn, Sub-adult, Adult, and Old—were sequenced to capture dynamic molecular changes. Our findings highlight distinct metabolic patterns between sexes: males exhibit elevated ion metabolism during infancy, while females show a metabolic peak post-adulthood, with enhanced fat metabolism during infancy. Time-series and regulatory network analyses indicate that the downregulation of stress-resistance genes such as FOXO is a key molecular driver of aging in this species. This dataset provides valuable insights into the physiological aging processes and sex-specific adaptations of Père David's Deer, contributing essential molecular information for its conservation.","dates":{"publication":"2026/05/20"},"accession":"GSE303008","cross_references":{"GSM":["GSM9115562","GSM9115563","GSM9115564","GSM9115565","GSM9115580","GSM9115560","GSM9115561","GSM9115548","GSM9115549","GSM9115566","GSM9115567","GSM9115568","GSM9115569","GSM9115573","GSM9115551","GSM9115574","GSM9115552","GSM9115553","GSM9115575","GSM9115576","GSM9115554","GSM9115570","GSM9115571","GSM9115550","GSM9115572","GSM9115559","GSM9115555","GSM9115577","GSM9115578","GSM9115556","GSM9115579","GSM9115557","GSM9115558"],"GPL":["36044"],"GSE":["303008"],"taxon":["Elaphurus davidianus"]}}