{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303044/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303044"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Toxicological assessment of microplastic exposure on Rats","description":"Microplastics, derived largely from degraded household and commercial plastics, have become a pervasive environmental concern, and may pose health risks resulting from ingestion and accumulation in living organisms. Polyethylene terephthalate (PET) microplastics, commonly found in consumer products such as plastic bottles and clothing, have been detected in human arteries and brains among other tissues—although their health impacts remain unknown. This study aimed to evaluate sex-based differences in biological effects of a single oral gavage of PET microplastics Sprague-Dawley rats. Adult rats (3 mo) were exposed to PET through oral gavage for approximately 18.5 hr. At the completion of the exposure, rats were evaluated for changes in metabolic rate and blood markers of inflammation, metabolism, stress, and stress. Rats were euthanized and liver, stomach, and duodenal tissue were used to identify exposure dependent changes in gene expression. Minor sex-dependent differences were observed in metabolic rate, metabolic biomarkers, and blood platelet concentration. Consistent with this, RNA-seq analysis identified few differentially expressed genes in either sex. No overlap among DEGs across all three tissues was observed between males and females. Together these results suggest that even in short term exposures PET alters diverse endpoints across tissues in a sex-dependent manner. Though effects were relatively minor, evaluating the effects of PETs in chronic studies is merited.","dates":{"publication":"2026/07/07"},"accession":"GSE303044","cross_references":{"GSM":["GSM9116377","GSM9116410","GSM9116376","GSM9116412","GSM9116379","GSM9116378","GSM9116411","GSM9116373","GSM9116372","GSM9116375","GSM9116374","GSM9116418","GSM9116417","GSM9116414","GSM9116413","GSM9116416","GSM9116415","GSM9116371","GSM9116370","GSM9116366","GSM9116365","GSM9116401","GSM9116368","GSM9116400","GSM9116367","GSM9116362","GSM9116361","GSM9116364","GSM9116363","GSM9116407","GSM9116406","GSM9116409","GSM9116408","GSM9116403","GSM9116369","GSM9116402","GSM9116405","GSM9116404","GSM9116360","GSM9116355","GSM9116354","GSM9116357","GSM9116356","GSM9116351","GSM9116350","GSM9116353","GSM9116352","GSM9116359","GSM9116358","GSM9116344","GSM9116343","GSM9116346","GSM9116345","GSM9116340","GSM9116342","GSM9116341","GSM9116348","GSM9116347","GSM9116349","GSM9116333","GSM9116332","GSM9116299","GSM9116335","GSM9116334","GSM9116296","GSM9116295","GSM9116298","GSM9116331","GSM9116297","GSM9116330","GSM9116337","GSM9116336","GSM9116339","GSM9116338","GSM9116292","GSM9116291","GSM9116294","GSM9116293","GSM9116290","GSM9116289","GSM9116322","GSM9116321","GSM9116288","GSM9116324","GSM9116323","GSM9116285","GSM9116284","GSM9116320","GSM9116287","GSM9116286","GSM9116329","GSM9116326","GSM9116325","GSM9116328","GSM9116327","GSM9116281","GSM9116280","GSM9116283","GSM9116282","GSM9116278","GSM9116399","GSM9116311","GSM9116398","GSM9116310","GSM9116313","GSM9116312","GSM9116279","GSM9116395","GSM9116394","GSM9116397","GSM9116396","GSM9116319","GSM9116318","GSM9116315","GSM9116314","GSM9116317","GSM9116316","GSM9116391","GSM9116390","GSM9116393","GSM9116392","GSM9116300","GSM9116388","GSM9116387","GSM9116302","GSM9116389","GSM9116301","GSM9116384","GSM9116383","GSM9116386","GSM9116385","GSM9116308","GSM9116307","GSM9116309","GSM9116304","GSM9116303","GSM9116306","GSM9116305","GSM9116380","GSM9116382","GSM9116381"],"GPL":["36046"],"GSE":["303044"],"taxon":["Rattus norvegicus"],"PMID":["[41853959]"]}}