GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303148/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303148GEOGSEfalseA critical role of necroptosis in the oil cyst formation associated with autologous fat transplantationAutologous fat grafting is limited by unpredictable long-term outcomes, with oil cyst formation being a major complication whose molecular mechanisms remain elusive. We established a novel surgically-induced mouse model demonstrating that ischemia duration time as the primary driver of oil cyst pathogenesis. Through RNA-sequencing of viable grafts (n=5) versus oil cysts (n=5), we identified the activation of RIPK3-MLKL signaling axis, revealing necroptosis-related pathways as critical molecular divergences.2026/04/21GSE303148GSM9118831GSM9118832GSM9118830GSM9118828GSM9118839GSM9118829GSM9118837GSM9118838GSM9118835GSM9118836GSM9118833GSM911883423479303148Mus musculus[41857749]