{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303341/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303341"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation [ATAC-seq]","description":"We investigated Tfh cell differentiation across multiple levels of biological organization by integrating diverse data types through interpretable network-based approaches. Our multi-scale network framework successfully combines transcriptomic and epigenetic datasets, capturing known regulators of Tfh differentiation identified in numerous prior studies. Through this approach, we identify a core set of Tfh-associated genes that is conserved across various tissues and disease conditions. Although individual components of this core set have been reported previously, a central contribution of our study is the unbiased discovery and in-depth characterization of this conserved gene signature.","dates":{"publication":"2026/08/02"},"accession":"GSE303341","cross_references":{"GSM":["GSM9123826","GSM9123815","GSM9123816","GSM9123827","GSM9123813","GSM9123824","GSM9123814","GSM9123825","GSM9123819","GSM9123817","GSM9123828","GSM9123818","GSM9123822","GSM9123823","GSM9123820","GSM9123821"],"GPL":["18573"],"GSE":["303341"],"taxon":["Homo sapiens"],"PMID":["[40894583]"]}}