{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303342/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303342"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation [RNA-Seq]","description":"We investigated Tfh cell differentiation across multiple levels of biological organization by integrating diverse data types through interpretable network-based approaches. Our multi-scale network framework successfully combines transcriptomic and epigenetic datasets, capturing known regulators of Tfh differentiation identified in numerous prior studies. Through this approach, we identify a core set of Tfh-associated genes that is conserved across various tissues and disease conditions. Although individual components of this core set have been reported previously, a central contribution of our study is the unbiased discovery and in-depth characterization of this conserved gene signature.","dates":{"publication":"2026/08/02"},"accession":"GSE303342","cross_references":{"GSM":["GSM9123837","GSM9123838","GSM9123835","GSM9123836","GSM9123839","GSM9123829","GSM9123840","GSM9123830","GSM9123841","GSM9123844","GSM9123833","GSM9123834","GSM9123842","GSM9123831","GSM9123843","GSM9123832"],"GPL":["21697"],"GSE":["303342"],"taxon":["Homo sapiens"],"PMID":["[40894583]"]}}