GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303342/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303342GEOGSEfalseA unified network systems approach uncovers a core program underlying T follicular helper cell differentiation [RNA-Seq]We investigated Tfh cell differentiation across multiple levels of biological organization by integrating diverse data types through interpretable network-based approaches. Our multi-scale network framework successfully combines transcriptomic and epigenetic datasets, capturing known regulators of Tfh differentiation identified in numerous prior studies. Through this approach, we identify a core set of Tfh-associated genes that is conserved across various tissues and disease conditions. Although individual components of this core set have been reported previously, a central contribution of our study is the unbiased discovery and in-depth characterization of this conserved gene signature.2026/08/02GSE303342GSM9123837GSM9123838GSM9123835GSM9123836GSM9123839GSM9123829GSM9123840GSM9123830GSM9123841GSM9123844GSM9123833GSM9123834GSM9123842GSM9123831GSM9123843GSM912383221697303342Homo sapiens[40894583]