{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303343/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303343"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation [CUT&RUN]","description":"We investigated Tfh cell differentiation across multiple levels of biological organization by integrating diverse data types through interpretable network-based approaches. Our multi-scale network framework successfully combines transcriptomic and epigenetic datasets, capturing known regulators of Tfh differentiation identified in numerous prior studies. Through this approach, we identify a core set of Tfh-associated genes that is conserved across various tissues and disease conditions. Although individual components of this core set have been reported previously, a central contribution of our study is the unbiased discovery and in-depth characterization of this conserved gene signature.","dates":{"publication":"2026/08/02"},"accession":"GSE303343","cross_references":{"GSM":["GSM9123848","GSM9123849","GSM9123868","GSM9123846","GSM9123869","GSM9123847","GSM9123891","GSM9123892","GSM9123870","GSM9123890","GSM9123851","GSM9123873","GSM9123874","GSM9123852","GSM9123871","GSM9123872","GSM9123850","GSM9123877","GSM9123855","GSM9123878","GSM9123856","GSM9123875","GSM9123853","GSM9123854","GSM9123876","GSM9123859","GSM9123857","GSM9123879","GSM9123858","GSM9123880","GSM9123881","GSM9123884","GSM9123862","GSM9123885","GSM9123863","GSM9123860","GSM9123882","GSM9123883","GSM9123861","GSM9123888","GSM9123866","GSM9123845","GSM9123889","GSM9123867","GSM9123886","GSM9123864","GSM9123865","GSM9123887"],"GPL":["21697"],"GSE":["303343"],"taxon":["Homo sapiens"],"PMID":["[40894583]"]}}