{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303749/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303749"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"mRNA signatures of a T-cell driven Limbic Encephalitis mouse model","description":"To determine the key transcription factors and molecular pathways involved in Limbic Encephalitis (LE), we analyzed immune cell-driven transcriptional changes in a newly developed mouse model of CD8+ T cell-mediated LE. This murine model (OVA-CD8+ LE) recapitulates the essential phenotypic features observed in human cytotoxic T lymphocyte (CTL)-induced LE, including neuroinflammation and seizure susceptibility. In a time series approach 2, 5, 8 and 28 days post-injection hippocampal tissue was harvested for RNA sequencing analysis. These timepoints were selected to capture stage-specific transcriptional changes driven by CD8⁺ T cell activity, thereby providing insights into the molecular events underlying hippocampal dysfunction in LE.","dates":{"publication":"2026/07/09"},"accession":"GSE303749","cross_references":{"GSM":["GSM9135172","GSM9135171","GSM9674570","GSM9674572","GSM9674571","GSM9674574","GSM9674573","GSM9674554","GSM9674553","GSM9674575","GSM9674556","GSM9674555","GSM9674558","GSM9674557","GSM9674559","GSM9135170","GSM9674561","GSM9135165","GSM9674560","GSM9135167","GSM9674563","GSM9135166","GSM9674562","GSM9135169","GSM9674565","GSM9674564","GSM9135168","GSM9674567","GSM9674566","GSM9674569","GSM9674568"],"GPL":["24247"],"GSE":["303749"],"taxon":["Mus musculus"],"PMID":["[42415095]"]}}