GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303749/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303749GEOGSEfalsemRNA signatures of a T-cell driven Limbic Encephalitis mouse modelTo determine the key transcription factors and molecular pathways involved in Limbic Encephalitis (LE), we analyzed immune cell-driven transcriptional changes in a newly developed mouse model of CD8+ T cell-mediated LE. This murine model (OVA-CD8+ LE) recapitulates the essential phenotypic features observed in human cytotoxic T lymphocyte (CTL)-induced LE, including neuroinflammation and seizure susceptibility. In a time series approach 2, 5, 8 and 28 days post-injection hippocampal tissue was harvested for RNA sequencing analysis. These timepoints were selected to capture stage-specific transcriptional changes driven by CD8⁺ T cell activity, thereby providing insights into the molecular events underlying hippocampal dysfunction in LE.2026/07/09GSE303749GSM9135172GSM9135171GSM9674570GSM9674572GSM9674571GSM9674574GSM9674573GSM9674554GSM9674553GSM9674575GSM9674556GSM9674555GSM9674558GSM9674557GSM9674559GSM9135170GSM9674561GSM9135165GSM9674560GSM9135167GSM9674563GSM9135166GSM9674562GSM9135169GSM9674565GSM9674564GSM9135168GSM9674567GSM9674566GSM9674569GSM967456824247303749Mus musculus[42415095]