GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303810/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303810GEOGSEfalsesnRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitisAutoantibodies (ABs) against intracellular proteins, including glutamate-decarboxylase 65 (anti-GAD65), are increasingly recognized in autoimmune and limbic encephalitis (AE/LE). Anti-GAD65 LE frequently progresses into severe temporal lobe epilepsy (TLE), neuropathologically characterized by hippocampal sclerosis (HS) and variable cytotoxic T lymphocytes (CTLs) infiltration. Recently, we have identified Drebrin as a novel intracellular target protein of ABs in patients suspicious for AE. Here, we report on the hippocampal neuropathological sequelae and single-nuclei RNA sequencing (snRNA-seq) of anti-Drebrin- versus anti-GAD65-positive TLE patients, in concert with key clinical parameters from a large patient cohort.2026/07/09GSE303810GSM9136272GSM9136271GSM9136274GSM9136273GSM9136276GSM9136275GSM9136277GSM913627024676303810Homo sapiens[42415095]