{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303869/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303869"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"P2X7-mediated mitochondrial calcium overload induces CD8+ T cell senescence","description":"Neutral lipid levels (Bodipy 493/503) were increased in aged CD8⁺ T cells. We thus selectively removed the lipid sensing transcription factor Rxra and Rxrb in T-lineage cells (Cd4-Cre⁺/⁻ Rxra^f/f Rxrb^f/f; hereafter TDKO). Preliminary phenotyping confirmed that TDKO mice harbour a higher frequency of senescent (fSA-βGal⁺) CD8⁺ T cells relative to wild-type (WT) controls, prompting a comparative survey.","dates":{"publication":"2026/07/29"},"accession":"GSE303869","cross_references":{"GSM":["GSM9137152","GSM9137151","GSM9137153","GSM9137145","GSM9137147","GSM9137146","GSM9137149","GSM9137148","GSM9137150"],"GPL":["34328"],"GSE":["303869"],"taxon":["Mus musculus"]}}