{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303976/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303976"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"MInD: Multi-organ Invasion Device incorporating a 3D printed granular elastomer reveals cardiac resistance to cancer metastasis","description":"Despite the systemic spread of cancer, the ventricular myocardium remains one of the least common sites of metastasis—a phenomenon that remains poorly understood. To investigate this, we developed the Multi-organ Invasion Device (MInD), a dynamic organ-on-a-chip platform that enables multi-organ culture under flow. Organ compartments are connected in MInD using PermeoTubes—3D-printed conduits with multi-scale fractal porosity fabricated from a granular poly(octamethylene maleate (anhydride) citrate) (POMaC) ink to impart viscoelasticity and ECM-mimetic permeability that supported cancer cell intravasation, migration, and extravasation. Highly aggressive breast cancer cells preferentially invaded hepatic tissue, while invasion into cardiac tissue was markedly suppressed in both co- and tri-organ culture. Cytokine profiling and RNA sequencing revealed that cardiac co-culture downregulated pro-metastatic and immunosuppressive cytokines and upregulated immune-activating and anti-invasive genes. In contrast, hepatic co-culture promoted matrix remodeling, angiogenesis, and immune suppression. Overall, this platform provides a new approach for uncovering organ-specific drivers of metastasis and cardiac resistance to metastasis, paving the way for future discovery of metastasis-inhibiting therapies.","dates":{"publication":"2026/06/12"},"accession":"GSE303976","cross_references":{"GSM":["GSM9140067","GSM9140068","GSM9140069","GSM9140074","GSM9140075","GSM9140076","GSM9140065","GSM9140066","GSM9140070","GSM9140071","GSM9140072","GSM9140073"],"GPL":["34284"],"GSE":["303976"],"taxon":["Homo sapiens"]}}