{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304046/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304046"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A Neuroimmune Circuit that Regulates Allergic Inflammation in the Esophagus in Mice","description":"Eosinophilic esophagitis (EoE) is a chronic, allergic disease associated with refractory pain in patients, yet the function of the nervous system in EoE pathogenesis remains ill-defined. Here we elucidate a mouse neuroimmune circuit that is linked to type 2-associated allergic inflammation and clinical responses in the esophagus, including pain. In a mouse allergy model, allergen exposure evokes pain-like behavior, increases esophageal Nav1.8+ sensory innervation density, and alters nociceptor sensitization. Thoracic dorsal root ganglia (DRG) show allergen-induced expression of type 2 cytokine receptors Il4ra and Il13ra1, while IL-4 and IL-13 sensitize DRG neurons to noxious agents. Mechanistically, conditional deletion of Il4ra in mouse NaV1.8+ neurons attenuate the above allergen-induced phenotypes as well as the levels of insulin-like growth factor 1 (IGF1); in parallel, IGF-1 receptor inhibition also dampens these disease features. Finally, EoE patient samples show increased esophageal neuronal density when compared with controls. Our findings thus describe a type 2 neuroimmune circuit that potentially contributes to EoE pathogenesis, including pain.","dates":{"publication":"2026/08/25"},"accession":"GSE304046","cross_references":{"GSM":["GSM9141696","GSM9141652","GSM9141651","GSM9141695","GSM9141654","GSM9141698","GSM9141653","GSM9141697","GSM9141692","GSM9141691","GSM9141650","GSM9141694","GSM9141693","GSM9141690","GSM9141649","GSM9141648","GSM9141689","GSM9141688","GSM9141663","GSM9141662","GSM9141665","GSM9141664","GSM9141661","GSM9141660","GSM9141659","GSM9141656","GSM9141699","GSM9141655","GSM9141658","GSM9141657","GSM9141674","GSM9141673","GSM9141676","GSM9141675","GSM9141670","GSM9141672","GSM9141671","GSM9141708","GSM9141707","GSM9141709","GSM9141704","GSM9141703","GSM9141706","GSM9141705","GSM9141667","GSM9141700","GSM9141666","GSM9141702","GSM9141669","GSM9141668","GSM9141701","GSM9141685","GSM9141684","GSM9141687","GSM9141686","GSM9141681","GSM9141680","GSM9141683","GSM9141682","GSM9141715","GSM9141714","GSM9141717","GSM9141716","GSM9141711","GSM9141678","GSM9141710","GSM9141677","GSM9141713","GSM9141679","GSM9141712"],"GPL":["34328"],"GSE":["304046"],"taxon":["Mus musculus"]}}