GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304046/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304046GEOGSEfalseA Neuroimmune Circuit that Regulates Allergic Inflammation in the Esophagus in MiceEosinophilic esophagitis (EoE) is a chronic, allergic disease associated with refractory pain in patients, yet the function of the nervous system in EoE pathogenesis remains ill-defined. Here we elucidate a mouse neuroimmune circuit that is linked to type 2-associated allergic inflammation and clinical responses in the esophagus, including pain. In a mouse allergy model, allergen exposure evokes pain-like behavior, increases esophageal Nav1.8+ sensory innervation density, and alters nociceptor sensitization. Thoracic dorsal root ganglia (DRG) show allergen-induced expression of type 2 cytokine receptors Il4ra and Il13ra1, while IL-4 and IL-13 sensitize DRG neurons to noxious agents. Mechanistically, conditional deletion of Il4ra in mouse NaV1.8+ neurons attenuate the above allergen-induced phenotypes as well as the levels of insulin-like growth factor 1 (IGF1); in parallel, IGF-1 receptor inhibition also dampens these disease features. Finally, EoE patient samples show increased esophageal neuronal density when compared with controls. Our findings thus describe a type 2 neuroimmune circuit that potentially contributes to EoE pathogenesis, including pain.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 musculus