{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304109/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304109"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq profiling of SEM B-ALL cells silenced for KMT2A::AFF1 fusion circular RNA.","description":"The t(4;11) translocation, resulting in the KMT2A::AFF1 fusion gene, is associated with a poor prognosis in pediatric and adult B-cell Acute Lymphoblastic Leukemia (B-ALL). Recently, KMT2A::AFF1 fusion circular RNAs (f-circRNAs) were identified by bioinformatics in B-ALL; however, their contribution to leukemia has not been explored. In this context, we identified a novel recurrent back-splicing junction joining the AFF1 exon 8 to KMT2A exon 2 (AK_8_2), which was recurrent in t(4;11)-positive B-ALL cell lines as well as in pediatric and adult B-ALL patients. To investigate its functional role, we performed the total RNA-seq profiling of SEM B-ALL cells harboring the t(4;11) translocation and knocked-down for AK_8_2 f-circRNA, thus identifying a set of up-regulated genes potentially relevant for cell metabolism and leukemogenesis.","dates":{"publication":"2026/07/30"},"accession":"GSE304109","cross_references":{"GSM":["GSM9143721","GSM9143722","GSM9143720","GSM9143719","GSM9143723","GSM9143724"],"GPL":["30173"],"GSE":["304109"],"taxon":["Homo sapiens"]}}