{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304197/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304197"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Local niche-derived immunosuppressive CXCR2+ cells impair antiviral immunity [RNA-seq]","description":"The severity of symptoms after viral infection varies between individuals, yet the underlying mechanism remains poorly understood. We categorized mice with varying severity into recovering and non-recovering groups after infection of vesicular stomatitis virus (VSV). We revealed that non-recovering mice expressed higher levels of anti-inflammatory cytokines in the olfactory bulb (OB) where VSV initially expand. Importantly, CXCR2+ cells resembling immunosuppressive myeloid-derived suppressor cells (MDSCs) were more abundant in the OB of non-recovering mice than in that of recovering mice after VSV infection. Depleting CXCR2+ MDSC-like cells from the brain increased inflammatory responses and the animal’s survival after infection. Furthermore, site-specific labeling of cells derived from the skull-bone marrow (skull-BM) indicated that a significant fraction of CXCR2+ MDSC-like cells in the OB originate from the skull-BM. This study unveiled the lethal effects of CXCR2+ MDSC-like cells on local immune responses to viral infection, highlighting their therapeutic potential for antiviral defense.","dates":{"publication":"2026/09/05"},"accession":"GSE304197","cross_references":{"GSM":["GSM9144910","GSM9144909","GSM9144911","GSM9144912"],"GPL":["32159","30172"],"GSE":["304197"],"taxon":["Mus musculus"]}}