{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304318/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304318"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis - retina snRNA-seq data","description":"Triggered by the relevance of Piezo mechanosensitive ion channels in different organs with functions beyond touch and pain sensation, we aimed to investigate Piezo2 in the central nervous system with a focus on the anterior visual system, especially because its role in the CNS lacks understanding. We found a bimodal expression pattern with Piezo1 in progenitors and Piezo2 in mature oligodendrocytes, which was conserved between mice and humans. Using two different OL-specific loss-of-function approaches, we found Piezo2 to be relevant for myelin compactness and white matter integrity in aged mice. Ultrastructural imaging was paired with snRNA-seq analysis and motor function testing that confirmed regulatory roles of Piezo2 in motor function and white matter integrity. We complemented our work with a validation study in human control and multiple sclerosis optic nerve tissue, and found Piezo2 to be downregulated in OLs towards the lesion rim.","dates":{"publication":"2026/06/03"},"accession":"GSE304318","cross_references":{"GSM":["GSM9147360","GSM9589024","GSM9589025","GSM9147357","GSM9147358","GSM9147359","GSM9589022","GSM9589023"],"GPL":["24247"],"GSE":["304318"],"taxon":["Mus musculus"],"PMID":["[42323468]"]}}