{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304376/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Canis lupus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304376"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive transcriptome analysis of influenza A virus-infected MDCK cells treated with Mel56","description":"To identify the genes involved in the anti-influenza activity of Mel56, we performed an RNA sequencing (RNA-seq) analysis of IAV-infected MDCK cells treated with Mel56. A total of 1,767 differentially expressed genes (DEGs) were identified using |fold-change (FC)| ≥ 2 and raw p-value < 0.05 as thresholds for the comparison between Mel56-treated and DMSO-treated MDCK cells infected with A/PR/8/34 virus. Among these DEGs, 1,062 were upregulated and 705 were downregulated (≥2-FC) in response to Mel56 treatment.","dates":{"publication":"2026/04/13"},"accession":"GSE304376","cross_references":{"GSM":["GSM9149586","GSM9149585","GSM9149588","GSM9149587","GSM9149589","GSM9149590"],"GPL":["36086"],"GSE":["304376"],"taxon":["Canis lupus"],"PMID":["[42138434]"]}}