GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304388/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304388GEOGSEfalseRetinoic Acid-Mediated Signaling Regulates Allantoic and Fetoplacental VascularizationThe placenta is vital for fetal development, and altered placental vascularization underlies prevalent disorders, including fetal growth restriction, prematurity, and pregnancy complications. Impaired placental vascularization is associated with Vitamin A deficiency, but mechanisms are undefined. To investigate this, we used retinoic acid (RA)-deficient Raldh2⁻/⁻ embryos, and found they exhibit placental endothelial hyperproliferation and impaired arterial-venous remodeling, which were rescued by providing all‑trans‑RA (ATRA) via maternal diet. Single cell RNA sequencing of E9.5 Raldh2+/+, Raldh2⁻/⁻,and Raldh2⁻/⁻+ATRA placental cells, and functional assays, revealed that RA regulates endothelial growth and vascular remodeling via Notch signaling.2026/02/17GSE304388GSM9149797GSM9149799GSM9149798GSM9149801GSM9149800GSM914980230172304388Mus musculus