{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304521"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"SEX-DEPENDENT TYPE I INTERFERON SIGNALING EXACERBATES ALZHEIMER'S PATHOLOGY","description":"Alzheimer’s disease (AD) disproportionately affects women, but the biological basis for this sex difference remains unclear. Using transcriptomic profiling of postmortem human AD brain tissue, we identified a sex-specific enrichment of interferon-alpha (IFN-α) signaling pathways in females. This immune signature was recapitulated in APP/PS1 transgenic mouse models, where female mice exhibited greater amyloid pathology, neuroinflammation, and neurodegeneration compared to males.","dates":{"publication":"2026/05/12"},"accession":"GSE304521","cross_references":{"GSM":["GSM9453419","GSM9453417","GSM9152029","GSM9453418","GSM9152028","GSM9152034","GSM9152033","GSM9453420","GSM9152032","GSM9152031","GSM9453421","GSM9152038","GSM9152037","GSM9152036","GSM9152035","GSM9152030","GSM9152019","GSM9152018","GSM9152017","GSM9152023","GSM9152022","GSM9152021","GSM9152020","GSM9152027","GSM9152026","GSM9152025","GSM9152024","GSM9152061","GSM9152060","GSM9151998","GSM9152009","GSM9152008","GSM9152007","GSM9152006","GSM9151999","GSM9152012","GSM9152056","GSM9152055","GSM9152011","GSM9152054","GSM9152010","GSM9152053","GSM9152016","GSM9453404","GSM9152015","GSM9152059","GSM9453405","GSM9152058","GSM9152014","GSM9152013","GSM9152057","GSM9152052","GSM9152051","GSM9152050","GSM9453408","GSM9453409","GSM9453406","GSM9152039","GSM9453407","GSM9152001","GSM9453411","GSM9152045","GSM9152044","GSM9453412","GSM9152000","GSM9152043","GSM9453410","GSM9152042","GSM9453415","GSM9152005","GSM9152049","GSM9152004","GSM9152048","GSM9453416","GSM9152047","GSM9453413","GSM9152003","GSM9453414","GSM9152002","GSM9152046","GSM9152041","GSM9152040"],"GPL":["24247"],"GSE":["304521"],"taxon":["Mus musculus"]}}