GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304521/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304521GEOGSEfalseSEX-DEPENDENT TYPE I INTERFERON SIGNALING EXACERBATES ALZHEIMER'S PATHOLOGYAlzheimer’s disease (AD) disproportionately affects women, but the biological basis for this sex difference remains unclear. Using transcriptomic profiling of postmortem human AD brain tissue, we identified a sex-specific enrichment of interferon-alpha (IFN-α) signaling pathways in females. This immune signature was recapitulated in APP/PS1 transgenic mouse models, where female mice exhibited greater amyloid pathology, neuroinflammation, and neurodegeneration compared to males.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 musculus