{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304676/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304676"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Few-shot Learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism","description":"Artificial intelligence (AI)-driven drug discovery is often hindered by the “few-shot” data bottleneck and the limited representational power of traditional two-dimensional models, challenging the accurate identification of functional molecules. In this study, we addressed these challenges by establishing a high-precision screening platform, which leverages transfer learning to recognize the key 3D molecular features of T cell inhibitors. Using this approach, we identified Lutein as a novel, specific immunomodulatory agent from a natural product library. Integrated multi-omics analyses revealed that Lutein activates peroxisome proliferator-activated receptor gamma (PPARγ), suppressing glucose uptake and glycolysis, thereby selectively inhibiting Th1 cell differentiation. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis, Lutein treatment significantly restored Th1-mediated immune balance and alleviated pathological tissue damage. Our findings not only highlight the great potential of “few-shot” AI strategies that leverage transfer learning and 3D molecular features for the discovery of bioactive natural compounds, but also identify Lutein as a promising therapeutic candidate for ulcerative colitis.","dates":{"publication":"2026/08/03"},"accession":"GSE304676","cross_references":{"GSM":["GSM9155145","GSM9155144","GSM9155141","GSM9155140","GSM9155143","GSM9155142"],"GPL":["24676"],"GSE":["304676"],"taxon":["Homo sapiens"]}}