{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304707/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304707"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression profile of mutant mouse bearing nuclear YARS2 G186V,mitochondrial COI V421A, and double muations","description":"Leber hereditary optic neuropathy (LHON) is a paradigm for inherited retinal disorders. Nuclear modifier Yars2 was proposed to modify the phenotypic manifestation of LHON-associated mitochondrial DNA (mtDNA) mutations. However, the mechanism underlying retinal-specific effects of LHON-linked mitochondrial-nuclear interactions remains poorly understood and there has been no effective treatment or cure for this disorder. We use RNA-seq to investigate the retinal deficiencies caused by LHON-linked mtDNA (COI V421A) and nDNA (YARS2 G186V) mutations.","dates":{"publication":"2026/08/31"},"accession":"GSE304707","cross_references":{"GSM":["GSM9155578","GSM9155589","GSM9155588","GSM9155579","GSM9155585","GSM9155584","GSM9155587","GSM9155586","GSM9155581","GSM9155580","GSM9155583","GSM9155582"],"GPL":["21103"],"GSE":["304707"],"taxon":["Mus musculus"]}}