{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304727/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":[" Expression profiling by high throughput sequencing","Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304727"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pan-cancer single-cell atlas of mouse and human tumor-associated dendritic cells","description":"Dendritic cells (DCs) are critical inducers of anti-tumor immunity. Yet, a comprehensive mapping of mouse and human DC subsets and states in a cancer context is lacking. Aiming to address this knowledge gap, we have generated pan-cancer mouse and human tumor-associated DC (TADC) scRNA-seq atlases, encompassing 15 mouse tumor models and 10 human cancer types, within which we identified several lineage-defined DC subsets along with functional states. We show that TADCs acquire an inflammatory profile with tumor progression and that tumor-mediated reprogramming occurs within the DCs from lymph nodes of tumor-bearing mice. Importantly, we demonstrate that TADCs are conserved across mice and human, and that gene signatures of different TADC subsets/states correlate with patient outcomes. Overall, we provide an in-depth characterization of the TADC compartment in mouse and human cancers, which can improve our understanding of the tumor microenvironment and contribute to the development of new anti-cancer therapies.","dates":{"publication":"2026/03/19"},"accession":"GSE304727","cross_references":{"GSM":["GSM9155889","GSM9155900","GSM9155897","GSM9155886","GSM9155896","GSM9155885","GSM9155899","GSM9155888","GSM9155887","GSM9155898","GSM9155893","GSM9155892","GSM9155884","GSM9155895","GSM9155894","GSM9155891","GSM9155890"],"GPL":["24247","21626"],"GSE":["304727"],"taxon":["Mus musculus"]}}