GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304752/primaryOK200TranscriptomicsMus musculus Genome binding/occupancy profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304752GEOGSEfalseChromatin priming of skeletal stem progenitor cells governs cell fate during bone repairBone regeneration is driven by skeletal stem/progenitor cells (SSPCs), which form bone and cartilage after injury. SSPCs represent a diversity of cell populations localized in several bone compartments and adjacent skeletal muscles, with different contributions to bone healing. By generating 10X multiome datasets (i.e., combined single-nucleus RNA-seq and ATAC-seq) and CUT&Tag datasets, we uncovered specificing epigenetic priming of SSPCs at steady-state in muscle and periosteum that dictates their fate decision after a bone fracture.2026/09/23GSE304752GSM9786079GSM9156315GSM9786078GSM9156317GSM9156316GSM9786075GSM9786074GSM9786077GSM9786076GSM9786081GSM9156318GSM97860803447524247304752Mus musculus