{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304838/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus domesticus"," Mus musculus"," Mus musculus castaneus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304838"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A stem cell-derived neuronal culture model for mouse species variation in neurite growth","description":"Stem cell-derived neurons represent a powerful experimental system for the study of axon growth and regeneration, cutting cost and technical challenges. We developed an in vitro system using stem cell-derived motor neurons to investigate phenotypic differences in neurite growth between mouse subspecies. Previously, neurons in CAST/EiJ mice (Mus musculus castaneus) were reported to regrow CNS axons after injury to a greater degree than other strains. Here, we assayed neurite outgrowth from stem cell-neurons in a fully in vitro system, in the abscence of injury signals. In this system, CAST/EiJ neurons grew longer axons than those of C57BL/6J and 129S6/SvEv origin. Additionally, CASTx129 hybrid neurons exhibit comparable neurite growth to CAST/EiJ, indicating a dominant genetic effect.","dates":{"publication":"2026/04/06"},"accession":"GSE304838","cross_references":{"GSM":["GSM9157944","GSM9157945","GSM9157942","GSM9157943","GSM9157941","GSM9347164","GSM9347163","GSM9157948","GSM9157949","GSM9157946","GSM9157947"],"GPL":["33115","24247","29744"],"GSE":["304838"],"taxon":["Mus musculus domesticus"," Mus musculus"," Mus musculus castaneus"]}}