GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304838/primaryOK200TranscriptomicsMus musculus domesticus Mus musculus Mus musculus castaneusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304838GEOGSEfalseA stem cell-derived neuronal culture model for mouse species variation in neurite growthStem cell-derived neurons represent a powerful experimental system for the study of axon growth and regeneration, cutting cost and technical challenges. We developed an in vitro system using stem cell-derived motor neurons to investigate phenotypic differences in neurite growth between mouse subspecies. Previously, neurons in CAST/EiJ mice (Mus musculus castaneus) were reported to regrow CNS axons after injury to a greater degree than other strains. Here, we assayed neurite outgrowth from stem cell-neurons in a fully in vitro system, in the abscence of injury signals. In this system, CAST/EiJ neurons grew longer axons than those of C57BL/6J and 129S6/SvEv origin. Additionally, CASTx129 hybrid neurons exhibit comparable neurite growth to CAST/EiJ, indicating a dominant genetic effect.2026/04/06GSE304838GSM9157944GSM9157945GSM9157942GSM9157943GSM9157941GSM9347164GSM9347163GSM9157948GSM9157949GSM9157946GSM9157947331152424729744304838Mus musculus domesticus Mus musculus Mus musculus castaneus