GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304966/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304966GEOGSEfalseTranscriptomic profiling of A549 cells in response to dexamethasone, in the context of light-controlled GR degradation using novel GR-PhotoPROTACsGlucocorticoid receptor (GR) signaling, activated by dexamethasone (Dex), induces a reversible dormancy state in non-small cell lung cancer (NSCLC) cells, contributing to therapy resistance. To enable precise modulation of GR activity, we developed photoswitchable PROTACs (PhotoPROTACs) incorporating arylazopyrazole scaffolds that allow reversible, wavelength-specific control of GR degradation. A549 lung carcinoma cells were incubated with the active (E-isomer) or inactive (Z-isomer) form of PhotoPROTAC KH-5-309 or KH-5-306 for 12 hours, with Dex added during the final 2 hours. RNA sequencing revealed that the E-isomer of KH-5-309 selectively disrupts GR-driven dormancy-associated gene expression, while the Z-isomer remains functionally inert. This dataset provides a resource for understanding GR-mediated dormancy and demonstrates the utility of light-responsive chemical tools for spatiotemporal control of stress hormone receptor signaling to disrupt cancer cell dormancy.2026/05/21GSE304966GSM9160392GSM9160391GSM9160394GSM9160393GSM9160396GSM9160395GSM9160398GSM9160397GSM9160390GSM9160389GSM9160400GSM9197501GSM9160388GSM9160402GSM9160401GSM9160404GSM9160403GSM9160381GSM9197508GSM9197509GSM9160383GSM9197506GSM9197507GSM9160382GSM9197504GSM9160385GSM9160384GSM9197505GSM9160387GSM9197502GSM9160386GSM9197503GSM9197511GSM9197512GSM9160399GSM919751034284304966Homo sapiens