{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305032/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305032"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Tape strips capture immune and epidermal hyperplasia markers in the major orphan ichthyoses","description":"This pilot study examined gene expression in tape strip samples obtained from 9 patients with Netherton Syndrome (NS), 6 patients with congenital ichthyosiform erythroderma (CIE), 7 patients with lamellar ichthyosis (LI), and 5 patients with epidermolytic ichthyosis (EI), as well as from 18 demographically matched healthy controls. Differential expression was defined with |fold-change/FCH|>2 and false discovery rate/FDR<0.05. All subtypes shared significant Th17/Th22 upregulation, and Th2 products were particularly increased in NS. Tape strips additionally captured common increases in Th1 and IL4R upregulation in NS, LI, and EI. Epidermal differentiation complex/cornified envelope (EDC-CE) genes were increased in all or most subtypes. Changes in immune and EDC-CE tape-strip markers correlated significantly and positively with those measured in biopsies.","dates":{"publication":"2026/03/31"},"accession":"GSE305032","cross_references":{"GSM":["GSM9161283","GSM9161261","GSM9161282","GSM9161285","GSM9161263","GSM9161262","GSM9161284","GSM9161287","GSM9161265","GSM9161264","GSM9161286","GSM9161267","GSM9161300","GSM9161289","GSM9161288","GSM9161266","GSM9161281","GSM9161280","GSM9161279","GSM9161294","GSM9161272","GSM9161293","GSM9161271","GSM9161296","GSM9161274","GSM9161273","GSM9161295","GSM9161276","GSM9161298","GSM9161297","GSM9161275","GSM9161278","GSM9161299","GSM9161277","GSM9161290","GSM9161270","GSM9161292","GSM9161291","GSM9161302","GSM9161269","GSM9161268","GSM9161301","GSM9161304","GSM9161303","GSM9161305"],"GPL":["24014"],"GSE":["305032"],"taxon":["Homo sapiens"]}}