GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305032/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305032GEOGSEfalseTape strips capture immune and epidermal hyperplasia markers in the major orphan ichthyosesThis pilot study examined gene expression in tape strip samples obtained from 9 patients with Netherton Syndrome (NS), 6 patients with congenital ichthyosiform erythroderma (CIE), 7 patients with lamellar ichthyosis (LI), and 5 patients with epidermolytic ichthyosis (EI), as well as from 18 demographically matched healthy controls. Differential expression was defined with |fold-change/FCH|>2 and false discovery rate/FDR<0.05. All subtypes shared significant Th17/Th22 upregulation, and Th2 products were particularly increased in NS. Tape strips additionally captured common increases in Th1 and IL4R upregulation in NS, LI, and EI. Epidermal differentiation complex/cornified envelope (EDC-CE) genes were increased in all or most subtypes. Changes in immune and EDC-CE tape-strip markers correlated significantly and positively with those measured in biopsies.2026/03/31GSE305032GSM9161283GSM9161261GSM9161282GSM9161285GSM9161263GSM9161262GSM9161284GSM9161287GSM9161265GSM9161264GSM9161286GSM9161267GSM9161300GSM9161289GSM9161288GSM9161266GSM9161281GSM9161280GSM9161279GSM9161294GSM9161272GSM9161293GSM9161271GSM9161296GSM9161274GSM9161273GSM9161295GSM9161276GSM9161298GSM9161297GSM9161275GSM9161278GSM9161299GSM9161277GSM9161290GSM9161270GSM9161292GSM9161291GSM9161302GSM9161269GSM9161268GSM9161301GSM9161304GSM9161303GSM916130524014305032Homo sapiens