{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305072/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305072"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of endostatin administration on epididymal white adipose tissue gene expression in female mice during the day.","description":"Endostatin is an endogenous cleavage product of Collagen 18 type a 1, an extracellular matrix protein that has anti-angiogenic properties. Increasing evidence suggests that endostatin has metabolic benefits in obesity models independently from its anti-angiogenic effects. Furthermore, multiple reports have shown drastic reduction in weight gain with endostatin treatment with high fat diet, and cell -autonomous effects of endostatin on adipocytes. The pathways that regulate endostatin 's effects on adipocytes are elusive. We have determined that there is a sex- and time-dependent effect of endostatin on adipose tissue gene expression. Therefore, we treated female mice with endostatin, collected adipose tissue and performed Total RNA-seq on RNA extracted from the tissue.","dates":{"publication":"2026/04/08"},"accession":"GSE305072","cross_references":{"GSM":["GSM9161739","GSM9161738","GSM9161740","GSM9161742","GSM9161741","GSM9161744","GSM9161743","GSM9161737"],"GPL":["24247"],"GSE":["305072"],"taxon":["Mus musculus"]}}