{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305176/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305176"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Integration of cell-type resolved spatial proteomics and transcriptomics reveals novel mechanisms in early ovarian cancer","description":"High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for early-stage cancer detection and development of effective treatment stategies. We performed and integrated spatial cell-type resolved proteomics and paired transcriptomics across 25 women with precursor lesions of the fallopian tube and/or HGSC. Epithelial cell signatures revealed early activation of SUMOylation machinery, increased ATR and Wnt signaling, and enhanced MHC-I antigen presentation along the disease trajectory. The stroma exhibited extracellular matrix (ECM) remodeling and interferon-mediated inflammation. Serous tubal intraepithelial carcinomas (STICs) in cancer patients contained a pro-coagulative signature and reduced APOA1/2 compared to STICs in individuals without cancer. Functional studies confirmed the role of epithelial-derived TRIP13 and SUMOylation, and cancer-associated fibroblast-derived SULF1 and BGN in HGSC progression. These findings provide unique molecular insights into HGSC pathogenesis and identify potential new therapeutic targets for intervention.","dates":{"publication":"2026/08/01"},"accession":"GSE305176","cross_references":{"GSM":["GSM9163880","GSM9164056","GSM9164057","GSM9163881","GSM9164054","GSM9164055","GSM9163884","GSM9163885","GSM9164058","GSM9163882","GSM9163883","GSM9164059","GSM9164052","GSM9164053","GSM9164050","GSM9164051","GSM9163877","GSM9163998","GSM9163878","GSM9163999","GSM9163875","GSM9163996","GSM9163997","GSM9163876","GSM9163879","GSM9164045","GSM9163990","GSM9163991","GSM9164046","GSM9163870","GSM9164043","GSM9164044","GSM9163994","GSM9164049","GSM9163873","GSM9163874","GSM9163995","GSM9163871","GSM9163992","GSM9164047","GSM9163872","GSM9163993","GSM9164048","GSM9164041","GSM9164042","GSM9164040","GSM9163987","GSM9163866","GSM9163867","GSM9163988","GSM9163864","GSM9163985","GSM9163865","GSM9163986","GSM9163868","GSM9163989","GSM9163869","GSM9164070","GSM9164071","GSM9163899","GSM9163897","GSM9163898","GSM9163891","GSM9164067","GSM9163892","GSM9164068","GSM9164065","GSM9164066","GSM9163890","GSM9163895","GSM9163896","GSM9164069","GSM9163893","GSM9163894","GSM9164060","GSM9164063","GSM9164064","GSM9164061","GSM9164062","GSM9163888","GSM9163889","GSM9163886","GSM9163887","GSM9163798","GSM9163799","GSM9163797","GSM9163918","GSM9163919","GSM9163916","GSM9163917","GSM9163910","GSM9163911","GSM9163914","GSM9163915","GSM9163912","GSM9163913","GSM9163907","GSM9163908","GSM9163905","GSM9163906","GSM9163909","GSM9163900","GSM9163903","GSM9163904","GSM9163901","GSM9163902","GSM9163940","GSM9163819","GSM9163817","GSM9163938","GSM9163939","GSM9163818","GSM9163811","GSM9163932","GSM9163812","GSM9163933","GSM9163930","GSM9163931","GSM9163810","GSM9163936","GSM9163815","GSM9163937","GSM9163816","GSM9163934","GSM9163813","GSM9163814","GSM9163935","GSM9163808","GSM9163929","GSM9163809","GSM9163806","GSM9163927","GSM9163928","GSM9163807","GSM9163800","GSM9163921","GSM9163801","GSM9163922","GSM9163920","GSM9163804","GSM9163925","GSM9163805","GSM9163926","GSM9163802","GSM9163923","GSM9163803","GSM9163924","GSM9164012","GSM9164013","GSM9164010","GSM9164011","GSM9163840","GSM9163961","GSM9164016","GSM9164017","GSM9163841","GSM9163962","GSM9164014","GSM9163960","GSM9164015","GSM9163839","GSM9163954","GSM9164009","GSM9163833","GSM9163834","GSM9163955","GSM9163831","GSM9163952","GSM9164007","GSM9163832","GSM9164008","GSM9163953","GSM9163837","GSM9163958","GSM9163838","GSM9163959","GSM9163835","GSM9163956","GSM9163957","GSM9163836","GSM9164001","GSM9164002","GSM9164000","GSM9164005","GSM9163950","GSM9163951","GSM9164006","GSM9163830","GSM9164003","GSM9164004","GSM9163828","GSM9163949","GSM9163829","GSM9163943","GSM9163822","GSM9163823","GSM9163944","GSM9163820","GSM9163941","GSM9163942","GSM9163821","GSM9163826","GSM9163947","GSM9163948","GSM9163827","GSM9163824","GSM9163945","GSM9163825","GSM9163946","GSM9164034","GSM9163980","GSM9164035","GSM9164032","GSM9164033","GSM9163983","GSM9164038","GSM9163862","GSM9163984","GSM9164039","GSM9163863","GSM9163981","GSM9163860","GSM9164036","GSM9164037","GSM9163861","GSM9163982","GSM9164030","GSM9164031","GSM9163855","GSM9163976","GSM9163977","GSM9163856","GSM9163974","GSM9164029","GSM9163853","GSM9163854","GSM9163975","GSM9163859","GSM9163857","GSM9163978","GSM9163858","GSM9163979","GSM9164023","GSM9164024","GSM9164021","GSM9164022","GSM9163851","GSM9163972","GSM9164027","GSM9163852","GSM9163973","GSM9164028","GSM9163970","GSM9164025","GSM9163971","GSM9164026","GSM9163850","GSM9164020","GSM9163965","GSM9163844","GSM9163845","GSM9163966","GSM9163963","GSM9164018","GSM9163842","GSM9163843","GSM9163964","GSM9164019","GSM9163848","GSM9163969","GSM9163849","GSM9163846","GSM9163967","GSM9163968","GSM9163847"],"GPL":["34281"],"GSE":["305176"],"taxon":["Homo sapiens"]}}