{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305236/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Oryza sativa"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305236"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"BUI1, an actin cytoskeleton protein that confers durable and broad-spectrum resistance in rice","description":"The cytoskeleton functions as a dynamic intracellular structural scaffold, enabling cells to rapidly perceive biotic and abiotic stresses. During plant innate immune responses, the cytoskeleton undergoes actin remodeling. Using the rice-Magnaporthe oryzae pathosystem, we investigated changes in actin organization within host plant cells. Our results demonstrate that pattern-triggered immunity (PTI), induced by pathogen-associated molecular patterns (PAMPs), triggers a rapid but transient increase in actin filament abundance. This process depends on BUI1, a type-II formin protein. Disruption of actin filaments with latrunculin B not only suppresses this increase but also enhances host susceptibility. Furthermore, we show that BUI1 positively regulates broad-spectrum resistance against multiple pathogens by suppressing reactive oxygen species (ROS) scavenging. Together, these findings uncover a key mechanism by which receptor-mediated signaling reorganizes the host cytoskeleton during plant-pathogen interactions.","dates":{"publication":"2026/07/08"},"accession":"GSE305236","cross_references":{"GSM":["GSM9166499","GSM9166510","GSM9166498","GSM9166497","GSM9166496","GSM9166514","GSM9166513","GSM9166512","GSM9166511","GSM9166491","GSM9166495","GSM9166494","GSM9166493","GSM9166492","GSM9166507","GSM9166506","GSM9166505","GSM9166504","GSM9166509","GSM9166508","GSM9166520","GSM9166503","GSM9166502","GSM9166501","GSM9166500","GSM9166518","GSM9166517","GSM9166516","GSM9166515","GSM9166519"],"GPL":["27660"],"GSE":["305236"],"taxon":["Oryza sativa"],"PMID":["[42390795]"]}}