{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305242/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305242"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Sphk1 deletion in smooth muscle cells on murine arterial transcriptome in hypertension","description":"The function of the cardiovascular system is regulated by sphingosine-1-phosphate (S1P) signalling. Vascular sphingosine kinase 1 (Sphk1), an S1P-producing enzyme, is upregulated in hypertension (HTN), and mice lacking Sphk1 globally exhibit alleviated angiotensin II (AngII)-induced HTN. Identifying the cellular mechanisms that provide this protection remains challenging due to the pleiotropic action of S1P. To obtain mice lacking Sphk1 in smooth muscle cells (SMCs), Sphk1 f/f (flox/flox) mice were crossed with transgenic mice harboring Cre recombinase gene under control of the mouse smooth muscle protein 22-alpha/transgelin (SM22α/Tagln) promoter. Subsequently, resulting Sphk1f/-Tagln-cre+ offsprings were mated to Sphk1f/f mice to generate mice lacking Sphk1 specifically in SMCs (Sphk1f/fTagln-cre+, later referred to as SMC KO-Sphk1) and control mice (Sphk1f/fTagln-cre-, hereafter referred to as wild type (WTf/f) mice).","dates":{"publication":"2026/04/07"},"accession":"GSE305242","cross_references":{"GSM":["GSM9166631","GSM9166630","GSM9166635","GSM9166634","GSM9166633","GSM9166632","GSM9166628","GSM9166627","GSM9166626","GSM9166625","GSM9166629","GSM9166620","GSM9166641","GSM9166640","GSM9166624","GSM9166623","GSM9166622","GSM9166621","GSM9166639","GSM9166617","GSM9166616","GSM9166638","GSM9166637","GSM9166636","GSM9166619","GSM9166618"],"GPL":["24247"],"GSE":["305242"],"taxon":["Mus musculus"],"PMID":["[41944022]"]}}