{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305281/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305281"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Aberrant epithelialization: A plausible factor for the development of endometrial polyps [scRNA-seq]","description":"To explore cellular heterogeneity and differentiation trajectories in endometrial polyps (EPs), single-cell RNA sequencing was performed on five EP and four adjacent endometrial tissue (adEN) samples using the 10x Genomics platform (targeting ~5,000 cells per sample). Clustering analysis identified eight major cell types, including stromal, epithelial, endothelial, immune, perivascular, macrophage, B cells, and ciliated cells. Pseudotime trajectory reconstruction revealed altered stromal-to-epithelial transitions in EPs with intermediate clusters enriched for MECOM and EYA2, suggesting aberrant epithelial maturation and disrupted vascular remodeling as potential mechanisms underlying EP formation.","dates":{"publication":"2026/08/28"},"accession":"GSE305281","cross_references":{"GSM":["GSM9168180","GSM9168181","GSM9168179","GSM9168175","GSM9168176","GSM9168177","GSM9168178","GSM9168173","GSM9168174"],"GPL":["24676"],"GSE":["305281"],"taxon":["Homo sapiens"],"PMID":["[41712676]"]}}