GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305281/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305281GEOGSEfalseAberrant epithelialization: A plausible factor for the development of endometrial polyps [scRNA-seq]To explore cellular heterogeneity and differentiation trajectories in endometrial polyps (EPs), single-cell RNA sequencing was performed on five EP and four adjacent endometrial tissue (adEN) samples using the 10x Genomics platform (targeting ~5,000 cells per sample). Clustering analysis identified eight major cell types, including stromal, epithelial, endothelial, immune, perivascular, macrophage, B cells, and ciliated cells. Pseudotime trajectory reconstruction revealed altered stromal-to-epithelial transitions in EPs with intermediate clusters enriched for MECOM and EYA2, suggesting aberrant epithelial maturation and disrupted vascular remodeling as potential mechanisms underlying EP formation.2026/08/28GSE305281GSM9168180GSM9168181GSM9168179GSM9168175GSM9168176GSM9168177GSM9168178GSM9168173GSM916817424676305281Homo sapiens[41712676]