{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305282/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Caenorhabditis elegans"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305282"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome profiling of wild-type C. elegans and strains expressing wild-type or G2019S-mutant human LRRK2","description":"This study presents RNA sequencing data from Caenorhabditis elegans strains expressing human wild-type or G2019S-mutant LRRK2 in a pan-neuronal manner, as well as wild-type control animals. Samples were collected to investigate the transcriptomic effects of LRRK2 expression and mutation on aging-related biological processes. Total RNA was extracted from synchronized animals, and libraries were sequenced using the Illumina NovaSeq 6000 or MGISEQ-T7 platform. Clean reads were aligned to the C. elegans reference genome (WBcel235), and gene expression levels were quantified as FPKM.","dates":{"publication":"2026/08/01"},"accession":"GSE305282","cross_references":{"GSM":["GSM9168190","GSM9168186","GSM9168187","GSM9168188","GSM9168189","GSM9168182","GSM9168183","GSM9168184","GSM9168185"],"GPL":["26672"],"GSE":["305282"],"taxon":["Caenorhabditis elegans"]}}