{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305453/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305453"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"In vivo Perturb-seq uncovers key obstacles to heart repair and regeneration through direct reprogramming","description":"We investigated the mechanism underlying Calr suppression-enhanced cardiac reprogramming. As CALR functions as an ER-resident chaperone and Ca2+-binding protein, with Ca2+ acting as a second messenger in fate-determining pathways, particularly cardiogenesis we performed RNA-seq on MGTMyoS-induced MICFs transduced with shCalr or shNT at days 7 and 14 in vitro","dates":{"publication":"2026/03/21"},"accession":"GSE305453","cross_references":{"GSM":["GSM9177278","GSM9177279","GSM9177276","GSM9177287","GSM9177277","GSM9177281","GSM9177282","GSM9177280","GSM9177285","GSM9177274","GSM9177275","GSM9177286","GSM9177283","GSM9177273","GSM9177284"],"GPL":["24247"],"GSE":["305453"],"taxon":["Mus musculus"]}}