{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305500/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305500"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Progranulin insufficiency and TDP-43 overexpression interact to worsen FTD-related phenotypes in mice.","description":"Progranulin (GRN) mutations, which typically cause progranulin haploinsufficiency, cause frontotemporal dementia with TDP-43 pathology (FTD-TDP). It is not clear how progranulin insufficiency may cause FTD-TDP. Progranulin-insufficient mice develop FTD-related phenotypes without robust TDP-43 pathology, so we crossed crossed Grn+/- mice (RRID:MMRRC_036771-JAX) with transgenic mice expressing wild-type human TDP-43 (RRID:IMSR_JAX:012836) to investigate the effect of progranulin insufficiency on TDP-43 aggregation and TDP-43–related phenotypes.","dates":{"publication":"2026/06/08"},"accession":"GSE305500","cross_references":{"GSM":["GSM9178136","GSM9178125","GSM9178137","GSM9178126","GSM9178134","GSM9178145","GSM9178123","GSM9178146","GSM9178124","GSM9178135","GSM9178129","GSM9178127","GSM9178138","GSM9178139","GSM9178128","GSM9178140","GSM9178132","GSM9178143","GSM9178133","GSM9178144","GSM9178130","GSM9178141","GSM9178142","GSM9178131"],"GPL":["24247"],"GSE":["305500"],"taxon":["Mus musculus"]}}