GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305500/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305500GEOGSEfalseProgranulin insufficiency and TDP-43 overexpression interact to worsen FTD-related phenotypes in mice.Progranulin (GRN) mutations, which typically cause progranulin haploinsufficiency, cause frontotemporal dementia with TDP-43 pathology (FTD-TDP). It is not clear how progranulin insufficiency may cause FTD-TDP. Progranulin-insufficient mice develop FTD-related phenotypes without robust TDP-43 pathology, so we crossed crossed Grn+/- mice (RRID:MMRRC_036771-JAX) with transgenic mice expressing wild-type human TDP-43 (RRID:IMSR_JAX:012836) to investigate the effect of progranulin insufficiency on TDP-43 aggregation and TDP-43–related phenotypes.2026/06/08GSE305500GSM9178136GSM9178125GSM9178137GSM9178126GSM9178134GSM9178145GSM9178123GSM9178146GSM9178124GSM9178135GSM9178129GSM9178127GSM9178138GSM9178139GSM9178128GSM9178140GSM9178132GSM9178143GSM9178133GSM9178144GSM9178130GSM9178141GSM9178142GSM917813124247305500Mus musculus