{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305671/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305671"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated differentiation kinetics underlie essential role of DNA damage repair in cloned placentas [ChIP-Seq]","description":"To investigate the mechanisms underlying cloned placenta hyperplasia, we employed single-cell RNA and ATAC-seq multi-omics at the critical window of placental overgrowth. Our work offers the first comprehensive and novel single-cell–level dissection of developmental barriers in SCNT placentas, demonstrating that genomic instability constitutes the principal determinant of SCNT placental dysfunction, and outlines a feasible approach to improve reproductive cloning outcomes.","dates":{"publication":"2026/06/18"},"accession":"GSE305671","cross_references":{"GSM":["GSM9181666","GSM9181663","GSM9181662","GSM9181665","GSM9181664","GSM9181661","GSM9181660","GSM9181659"],"GPL":["24247"],"GSE":["305671"],"taxon":["Mus musculus"]}}