{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305673/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"," Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305673"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated differentiation kinetics underlie essential role of DNA damage repair in cloned placentas [scMutiomics]","description":"To investigate the mechanisms underlying cloned placenta hyperplasia, we employed single-nuclei RNA and ATAC-seq multi-omics at the critical window of placental overgrowth. Our work offers the first comprehensive and novel single-nuclei–level dissection of developmental barriers in SCNT placentas, demonstrating that genomic instability constitutes the principal determinant of SCNT placental dysfunction, and outlines a feasible approach to improve reproductive cloning outcomes.","dates":{"publication":"2026/06/18"},"accession":"GSE305673","cross_references":{"GSM":["GSM9675360","GSM9675362","GSM9675361","GSM9181681","GSM9181680","GSM9181683","GSM9675359","GSM9181682","GSM9181678","GSM9181677","GSM9181679","GSM9181685","GSM9181674","GSM9181684","GSM9181673","GSM9181676","GSM9181686","GSM9181675"],"GPL":["34290"],"GSE":["305673"],"taxon":["Mus musculus"]}}