GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305673/primary200OKGenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305673GEOGSEfalseDysregulated differentiation kinetics underlie essential role of DNA damage repair in cloned placentas [scMutiomics]To investigate the mechanisms underlying cloned placenta hyperplasia, we employed single-nuclei RNA and ATAC-seq multi-omics at the critical window of placental overgrowth. Our work offers the first comprehensive and novel single-nuclei–level dissection of developmental barriers in SCNT placentas, demonstrating that genomic instability constitutes the principal determinant of SCNT placental dysfunction, and outlines a feasible approach to improve reproductive cloning outcomes.2026/06/18GSE305673GSM9675360GSM9675362GSM9675361GSM9181681GSM9181680GSM9181683GSM9675359GSM9181682GSM9181678GSM9181677GSM9181679GSM9181685GSM9181674GSM9181673GSM9181684GSM9181676GSM9181686GSM918167534290305673Mus musculus