{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305941/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305941"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of upregulation of MiR-29c-3p on gene expression during proliferation and metastasis of gastric cancer cells","description":"MiR-29c-3p functions as a critical tumor suppressor in gastric cancer (GC) pathogenesis. Restoration of MiR-29c-3p expression significantly suppresses cellular proliferation, migration, and invasion, while inducing apoptosis and G1 phase arrest in GC cells. Transcriptomic profiling reveals that MiR-29c-3p modulates genes involved in signal transduction, angiogenesis, and extracellular matrix reorganization, primarily through inhibition of the PI3K/AKT signaling cascade. Mechanistically, MiR-29c-3p directly targets the SLC6A14 oncogene, as validated by RNA pull-down and dual-luciferase assays. This targeting is essential for MiR-29c-3p’s tumor-suppressive function: suppression of SLC6A14 blocks epithelial-mesenchymal transition (EMT) and inactivates PI3K/pAKT signaling in GC cells. Both in vitro and in vivo models confirm that MiR-29c-3p upregulation inhibits tumor progression via the SLC6A14-PI3K/AKT axis. Our findings establish a molecular framework wherein MiR-29c-3p antagonizes GC progression by directly repressing SLC6A14 and its downstream PI3K/AKT pathway, positioning MiR-29c-3p as a potential therapeutic target in GC management.","dates":{"publication":"2026/08/25"},"accession":"GSE305941","cross_references":{"GSM":["GSM9188331","GSM9188332","GSM9188333","GSM9188334","GSM9188335","GSM9188336","GSM9188337","GSM9188338","GSM9188339","GSM9188329","GSM9188340","GSM9188330"],"GPL":["29480"],"GSE":["305941"],"taxon":["Homo sapiens"]}}