{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306052/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306052"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic training licenses naïve CD8⁺ T cell metabolic fitness and function","description":"Naïve T cells maintain quiescence yet must respond rapidly to antigens, but how they prime this capacity is unclear. We identify histone variant H2A.Z as a key regulator of an epigenetic training program that licenses quiescent naïve CD8+ T cells for future activation. H2A.Z deficiency disrupts naïve T cell homeostasis and effector responses. Multi-omics reveals that H2A.Z is selectively deposited at OXPHOS gene promoters in quiescent naïve CD8+ T cells, priming the chromatin for rapid transcriptional induction. This training is developmentally instructed by tonic IL-7 signaling and regulated by transcription factor GABPα. Age-related decline in IL-7 signaling reduces H2A.Z occupancy and impairs T cell activation, while IL-7 supplementation or enforced H2A.Z expression rescues this defect. H2A.Z overexpression also enhances CAR-T cell stemness and antitumor efficacy. Our work defines an IL-7R–GABPα–H2A.Z–OXPHOS axis that epigenetically establishes metabolic and functional fitness in quiescent T cells, offering insights for immunotherapy targeting ageing and tumors.","dates":{"publication":"2026/08/10"},"accession":"GSE306052","cross_references":{"GSM":["GSM9192149","GSM9192167","GSM9192145","GSM9192146","GSM9192168","GSM9192169","GSM9192147","GSM9192148","GSM9192152","GSM9192130","GSM9192174","GSM9192175","GSM9192153","GSM9192131","GSM9192132","GSM9192154","GSM9192155","GSM9192133","GSM9192170","GSM9192171","GSM9192172","GSM9192150","GSM9192173","GSM9192151","GSM9192138","GSM9192139","GSM9192156","GSM9192134","GSM9192135","GSM9192157","GSM9192158","GSM9192136","GSM9192159","GSM9192137","GSM9192141","GSM9192163","GSM9192164","GSM9192142","GSM9192165","GSM9192143","GSM9192166","GSM9192144","GSM9192160","GSM9192161","GSM9192162","GSM9192140"],"GPL":["34290"],"GSE":["306052"],"taxon":["Mus musculus"]}}