{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306320/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306320"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA immunoprecipitation sequencing identifies RNA targets of Lin28b in PDAC cancer-associated fibroblasts","description":"This study uses RNA immunoprecipitation followed by sequencing (RIP-seq) to identify RNA targets of Lin28b in PDAC cancer-associated fibroblasts (CAFs). CAFs expressing either Flag-wild-type Lin28b (Lin28b-WT) or an RNA-binding deficient mutant (Flag-Lin28b-MU) were subjected to RIP-seq. Our analysis revealed that STING mRNA, a key component of the innate immune cGAS-STING pathway, is a direct target of Lin28b. This interaction leads to decreased STING mRNA stability and reduced STING protein levels, thereby suppressing type I interferon (IFN) production. These findings provide a mechanistic explanation for the immunosuppressive function of Lin28b in the PDAC tumor microenvironment.","dates":{"publication":"2026/06/21"},"accession":"GSE306320","cross_references":{"GSM":["GSM9197377","GSM9197375","GSM9197376","GSM9197374"],"GPL":["21103"],"GSE":["306320"],"taxon":["Mus musculus"]}}