GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306320/primaryOK200OtherMus musculusOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306320GEOGSEfalseRNA immunoprecipitation sequencing identifies RNA targets of Lin28b in PDAC cancer-associated fibroblastsThis study uses RNA immunoprecipitation followed by sequencing (RIP-seq) to identify RNA targets of Lin28b in PDAC cancer-associated fibroblasts (CAFs). CAFs expressing either Flag-wild-type Lin28b (Lin28b-WT) or an RNA-binding deficient mutant (Flag-Lin28b-MU) were subjected to RIP-seq. Our analysis revealed that STING mRNA, a key component of the innate immune cGAS-STING pathway, is a direct target of Lin28b. This interaction leads to decreased STING mRNA stability and reduced STING protein levels, thereby suppressing type I interferon (IFN) production. These findings provide a mechanistic explanation for the immunosuppressive function of Lin28b in the PDAC tumor microenvironment.2026/06/21GSE306320GSM9197377GSM9197375GSM9197376GSM919737421103306320Mus musculus