{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306392/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306392"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"iPSC-Derived Hepatocytes from Patients with MASLD Exhibit Early Mitochondrial Dysfunction","description":"iPSCs from 10 MASLD patients and 10 healthy control subjects genotyped for the I148M variant of PNPLA3 were differentiated to iPSC-Heps. Mitochondrial mass and function were assessed under basal culture conditions and following short-term exposure to exogenous palmitate. Outcomes included gene expression, mitochondrial oxygen consumption, ROS production and cellular energy status. iPSC-Heps from MASLD patients exhibited mitochondrial alterations characteristic of their diseased origin. The degree of mitochondrial dysfunction seen in MASLD iPSC-Heps was reminiscent of that described clinically in early MASLD, prior to progression to steatohepatitis. Mitochondrial alterations in MASLD iPSC-Heps occurred independently of PNPLA3 genotype.","dates":{"publication":"2026/08/25"},"accession":"GSE306392","cross_references":{"GSM":["GSM9198749","GSM9198759","GSM9198758","GSM9198769","GSM9198768","GSM9198757","GSM9198767","GSM9198755","GSM9198766","GSM9198754","GSM9198753","GSM9198764","GSM9198763","GSM9198752","GSM9198762","GSM9198751","GSM9198761","GSM9198750","GSM9198760","GSM9198770"],"GPL":["21290"],"GSE":["306392"],"taxon":["Homo sapiens"]}}