{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306610/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":[" Expression profiling by high throughput sequencing","Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306610"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spaceflight multi-omics reveals vulnerabilities of human germ cell development","description":"Exposure to microgravity, cosmic radiation, and other spaceflight conditions induces significant physiological adaptations in biological systems. While prior studies have characterized effects on stem cell self-renewal and differentiation, the biological impacts of spaceflight on human germ cell development remain unexplored. To address this gap, we deployed automated experimental platforms aboard China's Tianzhou-1 (TZ-1) and Tianzhou-6 spacecraft, enabling fluorescent morphological analysis and multi-omics profiling of stem cell derivatives under orbital conditions. These systems incorporated live-cell imaging, remote operation interfaces from Earth, and integrated sample preservation for time-point-specific specimen capture. Our experiments revealed that spaceflight significantly reduced germ cell yields and dysregulated translational profiles, particularly in cytoskeletal organization and extracellular matrix (ECM) interaction pathways. However, whole-exome sequencing and genome-wide methylation analyses confirmed genomic stability, with no statistically significant mutations during short-term spaceflight. This work establishes an automated platform for real-time analysis of human germ cell differentiation in orbital microgravity and provides a foundation for future space biology research.","dates":{"publication":"2026/06/02"},"accession":"GSE306610","cross_references":{"GSM":["GSM9204636","GSM9204635","GSM9204634","GSM9204633","GSM9204618","GSM9204639","GSM9204617","GSM9204638","GSM9204637","GSM9204632","GSM9204631","GSM9204630","GSM9204647","GSM9204625","GSM9204624","GSM9204646","GSM9204645","GSM9204623","GSM9204644","GSM9204622","GSM9204629","GSM9204628","GSM9204627","GSM9204648","GSM9204626","GSM9204621","GSM9204643","GSM9204642","GSM9204620","GSM9204641","GSM9204640","GSM9204619"],"GPL":["24676"],"GSE":["306610"],"taxon":["Homo sapiens"]}}