{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306764/suppl/filelist.txt"],"Raw":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306764/suppl/GSE306764_RAW.tar"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306764/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306764"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Cross-tissue single-cell atlas including central and peripheral immune tissues in experimental autoimmune myasthenia gravis (EAMG)","description":"Myasthenia gravis (MG) is an autoimmune disease with an incompletely understood mechanism and limited treatment options. MG is a systemic autoimmune disease, complex abnormal humoral and cellular immune responses play a crucial role in the pathogenesis of MG. The pathological changes involve not just individual immune tissues, but also complex interactions among multiple organs and systems. However, the majority of previous studies focused on abnormalities in peripheral blood and the thymus. With the development of high-throughput technology, several studies have unbiasedly revealed abnormal numbers and function of immune cells by single-cell RNA sequencing and, cytometry-of-time-flight/mass cytometry (CyTOF), indicated pivotal role of aberrant changes in innate immune cells, including monocytes and natural killer cell (NK), in the pathogenesis of MG. Nevertheless, these innate immune cells reside not only in blood, but also widely within the central and peripheral immune organ including bone marrow, thymus, spleen, and lymph nodes. But it is particularly difficult to collect these samples from patients and healthy control, hindering the comprehensive understanding of pathological mechanisms of MG. In the present study, single-cell sequencing technology was used to construct a cross-tissue single-cell atlas including bone marrow, thymus, spleen, lymph and whole blood in experimental autoimmune myasthenia gravis (EAMG) model","dates":{"publication":"2026/04/01"},"accession":"GSE306764","cross_references":{"GSM":["GSM9207340","GSM9207341","GSM9207339","GSM9207346","GSM9207347","GSM9207348","GSM9207342","GSM9207343","GSM9207344","GSM9207345"],"GPL":["18694"],"GSE":["306764"],"taxon":["Rattus norvegicus"],"PMID":["[41709234]"]}}